Veliparib Active in Patients with BRCA-Positive Breast, Ovarian Tumors
The PARP inhibitor veliparib exhibits antitumor activity and is safe and tolerable on a continuous dosing schedule when used for the treatment of patients with BRCA-positive and BRCA-wild type tumors.
In Early Breast Cancer, Outcomes Affected by Tumor Biology and Choice of Local Treatment
Breast conserving therapy (BCT) improves overall survival compared with other local treatments in patients with stage I breast cancer, according to an examination of the National Cancer Database (NCDB).
"Angelina Jolie Effect" Sparks More BRCA Testing at Cancer Center
September 2nd 2014The actress Angelina Jolie's decision to undergo a preventive double mastectomy after learning she carried the BRCA1 gene mutation-associated with an increased risk of breast and/or ovarian cancer-apparently sparked an "Angelina effect" on public health.
Subtype, pCR Predict Locoregional Recurrence Following Neoadjuvant Therapy
The combination of multiple independent factors minimized the impact of baseline stage for predicting locoregional recurrence (LRR) following neoadjuvant chemotherapy in patients with breast cancer, according to a large retrospective analysis presented in advance of the 2014 Breast Cancer Symposium.
Patient Decisions About Bilateral Mastectomy Influenced by Anxiety, Worry About Recurrence
One of the first studies to prospectively examine women's breast surgery preferences has revealed that newly diagnosed women with breast cancer who decide to undergo contralateral prophylactic mastectomy (CPM), may be making this decision as result of high anxiety and fear of recurrence, rather than relying on evidence-based information.
Some Surgical Complications Greater With Bilateral Versus Unilateral Mastectomy
September 2nd 2014Postsurgery complications are infrequent among breast cancer patients undergoing surgery with reconstruction; however, according to a large database study, the rates of certain complications, including reoperation, blood transfusion, and implant loss, are higher with bilateral mastectomy versus unilateral mastectomy.