Phase II Trial Looks to Study Optune's Efficacy in Grade III Recurrent Glioma
Researchers are hoping that a proposed phase II study exploring use of the Optune system in patients with recurrent grade III malignant glioma will expand the indications for the tumor treating fields (TTFields) device beyond its current FDA-approved use in recurrent grade IV glioblastoma.
Dr. O'Connell on a Phase II Trial to Evaluate Optune in Grade III Brain Cancer
November 19th 2016Daniel O'Connell, MD, University of California at Los Angeles, discusses a phase II trial testing the benefits of tumor treating fields with Optune for bevacizumab-naive patients with grade III malignant glioma.
Checkpoint Inhibitors Show Promise in Glioblastoma
Findings from the phase II trials KEYNOTE-028 of pembrolizumab and MEDI4736 (durvalumab) point to a role for checkpoint inhibitors in the treatment of glioblastoma multiforme, based on encouraging efficacy signals and safety data with the two agents.
Adding Ibudilast to Temozolomide Increases Apoptosis, Survival in Preclinical GBM Study
November 18th 2016Combination therapy with ibudilast and temozolomide for glioblastoma multiforme increased apoptosis and prolonged survival by significantly reducing macrophage inhibitory factor and receptor CD74 expression.
'Groundbreaking' Global Brain Cancer Trial Planned
November 22nd 2015An international coalition of experts is planning an innovative clinical trial aimed at speeding up the development of new treatments for patients with glioblastoma multiforme, putting into motion a biomarker-driven approach that has been employed in other malignancies.
Rindopepimut Combo Continues to Show Strong OS Benefit in Relapsed GBM
Treatment with the immunotherapy rindopepimut plus bevacizumab resulted in a 47% reduction in the risk of death compared with bevacizumab and a control for patients with relapsed glioblastoma multiforme.