|Videos|August 13, 2020

ASCO 2020 Data Updates: Metastatic HER2+ Breast Cancer

Author(s)Sara A. Hurvitz, MD, David Geffen School of Medicine, Aditya Bardia, MD, MPH, FASCO, Claudine Isaacs, MD, Lombardi Comprehensive Cancer Center

Key opinion leaders discuss various trial data presented at the ASCO (American Society of Clinical Oncology) 2020 Annual Meeting regarding the management of metastatic HER2-positive breast cancer.

Data from the following clinical trials is discussed:

Tucatinib versus placebo added to trastuzumab and capecitabine for patients with previously treated HER2+ metastatic breast cancer with brain metastases (HER2CLIMB).(Lin, ASCO 2020 Abstract 1005)
The recent FDA approvals for relapsed refractory HER2+ MBC:
- Trastuzumab deruxtecan in Previously Treated HER2+ Breast Cancer: DESTINY-BREAST01 (Modi, NEJM 2020)
- Fam-trastuzumab deruxtecan-nxki
- Tucatinib
- Neratinib
The potential role of trastuzumab deruxtecan in HER2-low expressing tumors: phase 3, DESTINY-Breast04; NCT03734029

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ASCO 2020 Data Updates: Metastatic HER2+ Breast Cancer

Data from the following clinical trials is discussed:

Tucatinib versus placebo added to trastuzumab and capecitabine for patients with previously treated HER2+ metastatic breast cancer with brain metastases (HER2CLIMB).(Lin, ASCO 2020 Abstract 1005)

The recent FDA approvals for relapsed refractory HER2+ MBC:Trastuzumab deruxtecan in Previously Treated HER2+ Breast Cancer: DESTINY-BREAST01 (Modi, NEJM 2020)Fam-trastuzumab deruxtecan-nxkiTucatinibNeratinib

Trastuzumab deruxtecan in Previously Treated HER2+ Breast Cancer: DESTINY-BREAST01 (Modi, NEJM 2020)

Fam-trastuzumab deruxtecan-nxki

Tucatinib

Neratinib

The potential role of trastuzumab deruxtecan in HER2-low expressing tumors: phase 3, DESTINY-Breast04; NCT03734029

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