Commentary

Video

Dr Iams on the Effect of the FLAURA2 Trial in EGFR-Mutant NSCLC

Wade T. Iams, MD, discusses the impact of the phase 3 FLAURA2 trial in patients with EGFR-mutant non–small cell lung cancer, highlighting the notable improvements in progression-free survival that the approach elicits.

Wade T. Iams, MD, assistant professor of medicine, Division of Hematology/Oncology, Vanderbilt-Ingram Cancer Center, discusses the impact of the phase 3 FLAURA2 trial (NCT04035486) in patients with EGFR-mutant non–small cell lung cancer (NSCLC) , highlighting the notable improvements in progression-free survival (PFS) that this approach elicits.

Investigators presented updated data from the trial during the International Association for the Study of Lung Cancer 2023 World Conference on Lung Cancer. Updated data from the study showed that osimertinib (Tagrisso) plus platinum-based chemotherapy and pemetrexed produced a statistically significant and clinically meaningful improvement in PFS when compared withosimertinib monotherapy in patients with advanced, EGFR-mutated disease.

Notably median PFS increased from 16.7 months with osimertinib alone to 25.5 months with the combinationin this patient group, Iams adds. The 12-month PFS rates were 80% with the combination and 66%, with single-agent osimertinib. The 24-month PFS rates were 57% vs 41%, respectively.

Iams emphasizes that this improvement in PFS closely aligns with previous hypotheses regarding the survival data, which solidify the use of osimertinib in the adjuvant setting. Moreover, survival data from FLAURA2 indicate that the addition of platinum-doublet chemotherapy to initial treatment regimens should be the standard approach for patients with metastatic EGFR-mutant NSCLC.

In summary, the data from FLAURA2 further demonstrate the potential benefits associated with the upfront use of combination therapy in metastatic EGFR-mutant NSCLC, Iams concludes.

Related Videos
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss unmet needs and future research directions in ALK-positive and ROS1-positive NSCLC.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for lorlatinib in ROS1-positive NSCLC after crizotinib and chemotherapy.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for taletrectinib in ROS1-positive advanced non–small cell lung cancer.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, on progression patterns and subsequent therapies after lorlatinib in ALK-positive NSCLC.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss preclinical CNS data for the ROS1 inhibitor zidesamtinib.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for zidesamtinib in ROS1-positive non–small cell lung cancer.
Yair Lotan, MD, UT Southwestern Medical Center
Alan Tan, MD, Vanderbilt-Ingram Cancer Center
Alex Herrera, MD
Roy S. Herbst, MD, PhD