|Videos|August 13, 2020

Metastatic HR+ Breast Cancer Updates

Author(s)Sara A. Hurvitz, MD, David Geffen School of Medicine, Aditya Bardia, MD, MPH, FASCO, Claudine Isaacs, MD, Lombardi Comprehensive Cancer Center

Experts in the management of breast cancer consider data updates presented at the ASCO (American Society of Clinical Oncology) 2020 Annual Meeting regarding metastatic HR-positive breast cancer.

Data from the following clinical trials is discussed:

PARSIFAL: A randomized, multicenter, open-label, phase II trial to evaluate palbociclib in combination with fulvestrant or letrozole in endocrine-sensitive patients with ER[+]/HER2[-] metastatic breast cancer. (Borrego, ASCO 2020 Abstract 1007)
Alpelisib + fulvestrant in patients with PIK3CA-mutated HR+/HER2– advanced breast cancer (ABC) previously treated with CDK 4/6 inhibitor + aromatase inhibitor: BYLieve study results.(Rugo, ASCO 2020 Abstract 1006)

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Metastatic HR+ Breast Cancer Updates

Data from the following clinical trials is discussed:

PARSIFAL: A randomized, multicenter, open-label, phase II trial to evaluate palbociclib in combination with fulvestrant or letrozole in endocrine-sensitive patients with ER[+]/HER2[-] metastatic breast cancer. (Borrego, ASCO 2020 Abstract 1007)

Alpelisib + fulvestrant in patients with PIK3CA-mutated HR+/HER2– advanced breast cancer (ABC) previously treated with CDK 4/6 inhibitor + aromatase inhibitor: BYLieve study results.(Rugo, ASCO 2020 Abstract 1006)

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