Decoding HER2+ Breast Cancer: Challenges in Brain Metastases
Experts explore the intricacies of managing brain metastases in HER2+ breast cancer and delve into the latest evidence, patient considerations, and evolving guidelines for this complex scenario.
EP: 1.Evolving HER2+ Breast Cancer Care: Neo-Adjuvant Strategies and Treatment Goals
EP: 2.Neoadjuvant Approaches in HER2+ Breast Cancer
EP: 3.HER2+ Breast Cancer: Anthracycline Considerations
EP: 4.Subcutaneous HER2+ Breast Cancer Treatment Trends
EP: 5.Adjuvant Strategies in HER2+ Brest Cancer: Timing and Tailoring
EP: 6.Evolving Strategies in Adjuvant HER2+ Breast Cancer
EP: 7.Exploring Therapeutic Avenues in HER2+ Breast Cancer
EP: 8.Metastatic HER2+ Breast Cancer: Current Strategies and Ongoing Trials
EP: 9.Navigating Second-Line Choices in HER2+ Breast Cancer
EP: 10.Decoding HER2+ Breast Cancer: Challenges in Brain Metastases
EP: 11.Navigating HER2+ Brain Metastases: Emerging Insights
EP: 12.HER2+ Breast Cancer Treatment Dynamics and Challenges
EP: 13.Navigating Treatment Challenges in HER2+ Breast Cancer
EP: 14.Insights and Challenges in Advancing HER2+ Breast Cancer Care
This is a video synopsis/summary of a Peer Exchange involving Joyce O’Shaughnessy, MD; Priyanka Sharma, MD; Claudine Isaacs, MD; Heather McArthur, MD; and Hope S. Rugo, MD, FASCO.
O’Shaughnessy and Rugo discuss the management of HER2-positive breast cancer with brain metastases, highlighting the impact of the HER2CLIMB trial on treatment decisions. Rugo emphasizes the survival advantage observed in patients with active brain metastases, particularly with the tucatinib regimen, as demonstrated in the trial. The discussion delves into the challenges of treating patients with asymptomatic brain metastases and the evolving role of surveillance brain MRIs. Rugo sheds light on a flatiron database analysis, showcasing the cumulative incidence of brain metastases over time in patients with HER2-positive breast cancer. The findings reveal that by the third line of therapy, almost all patients with HER2-positive disease prone to brain metastases have developed them. This early occurrence differs from other breast cancer subtypes. The discussion underscores the complexities of treating brain metastases and the need for tailored approaches based on evolving evidence.
Video synopsis is AI-generated and reviewed by OncLive® editorial staff.
