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|Videos|January 24, 2022

SABCS 2021: Brain Metastases Updates in Breast Cancer

Author(s)Virginia G. Kaklamani, MD, DSc, Anne P. O’Dea, MD, Yara Abdou, MD

Focusing on datasets from the SABCS 2021 Virtual Meeting, panelists consider novel approaches to the management of brain metastases in breast cancer.

Episodes in this series

Expert on Breast Cancer

EP. 1 Coming Soon, HER2-Positive Breast Cancer: A Review of Data from the SABCS 2021 Virtual Meeting

Experts on Breast Cancer

EP. 2 SABCS 2021: Updates in Metastatic Breast Cancer

Experts on Breast Cancer

EP. 3 SABCS 2021: Brain Metastases Updates in Breast Cancer

Experts on Breast Cancer

EP. 4 SABCS 2021: Novel Approaches to Breast Cancer Management

Data from the following clinical trials are discussed:

PD4-02: Safety and efficacy of a tucatinib-trastuzumab-capecitabine regimen for treatment of leptomeningeal metastasis in HER2+ breast cancer: Results from TBCRC049, a phase 2 nonrandomized study
PD4-04: Updated results of tucatinib vs placebo added to trastuzumab and capecitabine for patients with previously treated HER2+ metastatic breast cancer with brain metastases (HER2CLIMB)
P1-18-26: Intracranial efficacy of tucatinib, palbociclib, and letrozole combination in patients with HR+/HER2+ breast cancer and brain metastases
P1-21-03: Efficacy of tyrosine kinase inhibitors (TKIs) in the treatment of patients with HER2+ breast cancer with or without brain metastases: a systematic review and meta-analysis
OT1-13-01: HER2CLIMB-04: phase 2 trial of tucatinib + trastuzumab deruxtecan in patients with HER2+ locally advanced or metastatic breast cancer with and without brain metastases

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