OncClub

Alex F. Herrera, MD, discusses key data from the phase 3 S1826 trial (NCT03907488) evaluating nivolumab plus AVD vs brentuximab vedotin plus AVD in adolescent and adult patients with stage III or IV advanced-stage classic Hodgkin lymphoma.

Shyam A. Patel, MD, PhD, discusses data from a meta-analysis that explored donor-engrafted clonal hematopoiesis's effects in allogeneic and autologous stem cell transplantation.

Sagar Lonial, MD, FACP, discusses findings from the observational CoMMpass study, which evaluated subtypes of multiple myeloma and identified high-risk genetic markers in patients with this disease.

Emil Lou, MD, PhD, FACP, discusses data from a study evaluating whether tumor-stroma proportion can predict chemoresistance and other outcomes in patients with ovarian cancer.

Kara N. Maxwell, MD, PhD, discusses data from a review published in JAMA Oncology which found that despite BRCA mutations being known actionable alterations, genetic testing rates for these aberrations are significantly lower in males compared with females.

Heinz-Josef Lenz, MD, discusses the findings of a retrospective study examining the correlation between HER2 expression and treatment outcomes in colorectal cancer.

Amin Nassar, MD, and Elias Bou Farhat, MD, discuss data from a retrospective study that examined whether next-generation sequencing could be utilized alongside standard immunohistochemistry to detect mismatch repair deficiency that might otherwise be missed in patients with colorectal cancer or endometrial cancer.

Michael Feigin, PhD, discusses the benzodiazepines lorazepam and alprazolam and their varying impacts on progression-free survival outcomes for patients with pancreatic cancer.

Paul G. Richardson, MD, discusses safety and efficacy findings observed with mezigdomide in combination with dexamethasone in heavily pretreated patients with relapsed/refractory multiple myeloma.

Jennifer M. King, MD, discusses the need for improved guidance when determining the appropriate management strategy for patients with residual nonretroperitoneal testicular cancer and findings from a study on the association between the presence of teratoma in the primary orchiectomy and the rate of teratoma in this disease.

Matthew Ehrhardt, MD, MS, discusses findings from a recent study which suggested that modifiable chronic health conditions may relate to social determinants of health and that these factors can lead to late mortality for survivors of childhood cancer.

Andrzej Jakubowiak, MD, PhD, discusses interim data from the phase 3 ATLAS trial (NCT02659293), which evaluated lenalidomide (Revlimid) plus carfilzomib (Kyprolis) and dexamethasone vs lenalidomide maintenance in patients with newly diagnosed multiple myeloma who had previously received induction therapy and autologous stem cell transplant.

Amar U. Kishan, MD, provides insight on the phase 3 MIRAGE study (NCT04384770), which showed that the use of MRI-guided stereotactic body radiotherapy resulted in a significant reduction in acute genitourinary and gastrointestinal toxicity compared with standard computed tomography–guided radiation.

Nabil F. Saba, MD, FACP, discusses data from a phase 2 trial (NCT03468218), which showed that pembrolizumab (Keytruda) plus cabozantinib (Cabometyx) elicited an overall response rate of 45.2% in patients with recurrent metastatic head and neck squamous cell carcinoma.

Andrew L. Pecora, MD, discusses the phase 3 DREAMseq trial (NCT02224781), which showed that nivolumab (Opdivo) plus ipilimumab (Yervoy) should be administered prior to the combination of a BRAF and MEK inhibitor in patients with advanced BRAF-mutant melanoma.

Yasir Y. Elamin, MD, discusses findings from a phase 2 study (NCT03066206), which found that poziotinib induced an investigator-assessed overall response rate of 32% in patients with non–small cell lung cancer harboring EGFR exon 20 mutations.

Matthew H. G. Katz, MD, sheds light on the phase 2 A021501 trial (NCT02839343), which showed that neoadjuvant mFOLFIRINOX provided a favorable overall survival benefit in patients with borderline resectable pancreatic ductal adenocarcinoma when administered prior to pancreatectomy.

Andrew J. Armstrong, MD, MSc, discusses updated data from the phase 3 ARCHES trial (NCT02677896) examining enzalutamide (Xtandi) plus androgen deprivation therapy in patients with metastatic hormone-sensitive prostate cancer, and the clinical implications of the research for this population.

Justin Taylor, MD, discusses the significance of BTK inhibition in patients with chronic lymphocytic leukemia, describes genomic analyses examining resistance mechanisms to the noncovalent BTK inhibitor pirtobrutinib (Jaypirca), and underscores the clinical significance of the data yielded from the research.

Muhammad Bilal Abid, MD, MRCP, highlights the clinical takeaways from a study examining the effectiveness of a third SARS-CoV-2 mRNA vaccine dose among patients treated with hematopoietic cell transplantation, CAR T-cell therapy, and bispecific antibodies.

Sameek Roychowdhury, MD, PhD, contextualizes safety and efficacy data reported from a phase 2 study (NCT02150967) examining infigratinib (Truseltiq) in patients with FGFR2-positive cholangiocarcinoma, describes nuances to treatment with the agent, and sheds light on ongoing research efforts being made to further improve outcomes in this population.

Muhammad Bilal Abid, MD, MRCP, discusses findings from a study outlining what is known about the risk of infections with CAR T-cell therapy and determinants of SARS-CoV-2 responses.

Co-authors Jacob Scott, MD, DPhil, and Javier Torres-Roca, MD, discuss their study, which found that genomic-adjusted radiation dose had a significant association with time to first recurrence and overall survival in patients with certain solid tumors who had received radiation therapy, indicating that genomics should be used to guide dosing decisions.

Chris Labaki, MD, and Quoc-Dien Trinh, MD, shed light on their research detailing a decline in cancer screenings during the height of the COVID-19 pandemic, the recovery of this testing, and existing disparities to be addressed with additional efforts.

Balazs Halmos, MD, discusses findings from a study he participated on, which found that COVID-19 vaccination induced high rates of seroconversion in patients with cancer, although those with hematologic malignancies had lower immunogenicity and those who received prior immunosuppressive therapies appeared to be less responsive.

C. Ola Landgren, MD, PhD, discusses data from the phase 2 MANHATTAN trial, which showed that carfilzomib (Kyprolis), lenalidomide (Revlimid), dexamethasone, and daratumumab (Darzalex) yielded high rates of minimal residual disease negativity in patients with newly diagnosed multiple myeloma.

C.Ola Landgren, MD, PhD, and Francesco Maura, MD, discuss their study exploring the utility of whole-genome sequencing in patients with monoclonal gammopathy of uncertain significance and smoldering myeloma to see whether they could identify genomic signatures capable of predicting progression to multiple myeloma.

Sophia George, PhD, and Judith E. Hurley, MD, walk through their study which found that 1 in 7 Caribbean-born adults with either breast or ovarian cancer had hereditary disease with an actionable pathogenic variant, providing opportunities for targeted therapies and unique preventative approaches.

Ghaith Abu-Zeinah, MD, shares data from a retrospective study which indicated that interferon-alpha significantly improved myelofibrosis-free survival and overall survival over hydroxyurea (Hydrea) and phlebotomy only in patients with polycythemia vera.

Co-authors Toni K. Choueiri, MD and Robert J. Motzer, MD, discuss how data from the phase 3 CheckMate-9ER trial (NCT03121177) confirmed the advantage of frontline cabozantinib (Cabometyx) plus nivolumab (Opdivo) vs sunitinib (Sutent) in terms of survival and responses in patients with advanced renal cell carcinoma.