ESMO 2024: Treatment of uHCC

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Panelists discuss how recent advancements in frontline and second-line therapies for unrespectable hepatocellular carcinoma (uHCC) are reshaping treatment strategies and improving patient outcomes.

Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

EP. 1: Current Treatment Landscape – difference between unresectable (uHCC) and metastatic (mHCC)

October 7th 2024

Panelists discuss the current landscape of first-line treatment for unresectable hepatocellular carcinoma, highlighting key options and decision-making factors.

Treatment Decisions Based on BLCL Stage

EP. 2: Treatment Decisions Based on BLCL Stage

October 7th 2024

Panelists discuss current treatment options for unresectable hepatocellular carcinoma, including atezolizumab plus bevacizumab, durvalumab plus tremelimumab, and transarterial chemoembolization, along with the factors influencing treatment decisions.

Current Treatment in First Line – IO + TKI or IO + IO

EP. 3: Current Treatment in First Line – IO + TKI or IO + IO

October 18th 2024

Panelists discuss current treatment options for unresectable hepatocellular carcinoma, including atezolizumab plus bevacizumab, durvalumab plus tremelimumab, and transarterial chemoembolization, along with the factors influencing treatment decisions.

Use of monotherapy (IO or TKI) or localized treatment in First Line

EP. 4: Use of monotherapy (IO or TKI) or localized treatment in First Line

October 18th 2024

Panelists discuss the circumstances under which monotherapy with a tyrosine kinase inhibitor or immunotherapy would be preferred in the treatment of unresectable hepatocellular carcinoma.

Discussion and Summary

EP. 5: Discussion and Summary

October 25th 2024

Panelists discuss the findings from the LEAP-012 study, which explores the efficacy of transarterial chemoembolization combined with lenvatinib and pembrolizumab in patients with Child-Pugh class A disease and intermediate-stage hepatocellular carcinoma.

LEAP-012 Study Results

EP. 6: LEAP-012 Study Results

October 25th 2024

Panelists discuss the results of the LEAP-012 study, highlighting the efficacy of transarterial chemoembolization combined with lenvatinib and pembrolizumab in patients with intermediate-stage hepatocellular carcinoma and Child-Pugh class A disease.