Experts discuss several recent data updates in the treatment of myeloproliferative neoplasms (MPNs) and the impact on clinical practice.
EP. 1: An Overview of Myeloproliferative Neoplasms (MPNs)
Experts provide an overview of myeloproliferative neoplasms, including the subtypes, process of diagnosis as well as reviewing the role of biomarkers.
EP. 2: Risk Assessment for Patients with Polycythemia Vera (PV)
Dr Jamile Shammo describes how risk is assessed for patients with polycythemia vera.
EP. 3: Current Treatment Landscape for Patients With PV
Drs Rampal and Yacoub details the currently available treatment options and reviews the rationale for use in patients with PV.
EP. 4: Selecting a Frontline Therapy for Patients With PV
Jamile Shammo, MD, explains how she decides on the most appropriate treatment option for a patient with polycythemia vera.
EP. 5: Ruxolitinib for the Management of PV
Abdulraheem Yacoub, MD, reviews data from the RESPONSE and RESPONSE-2 trials on the use of ruxolitinib for the treatment of polycythemia vera.
EP. 6: Ropeginterferon alfa-2b for the Treatment of PV
Dr Jamile Shammo reviews recent data on the treatment of patients with polycythemia vera with ropeginterferon.
EP. 7: Reviewing the Types of Myelofibrosis
The panel reviews the types of myelofibrosis, discusses how to risk stratify and explains the role of biomarker testing in patients with MF.
EP. 8: The Role of Transplant in the Treatment of Patients With MF
Dr Abdulraheem Yacoub explains allogeneic hematopoietic cell transplantation in myelofibrosis, the only known curative treatment modality.
EP. 9: COMFORT-I and COMFORT-II Data Review
Jamile Shammo, MD, comments the currently approved treatment options for patients with myelofibrosis and review data from the COMFORT-I and COMFORT-II trials, which evaluates the use of ruxolitinib in MF.
EP. 10: Pacritinib and Fedratinib for the Treatment of MF
Raajit Rampal, MD, and Abdulraheem Yacoub, MD, review data on the use of pacritinib and fedratinib in patients with myelofibrosis.
EP. 11: Sequencing Therapies in Patients with MF
Dr Jamile Shammo discusses how to approach sequencing therapies in patients with myelofibrosis and Dr Raajit Rampal explains the potential of the JAK inhibitor momelotinib in the treatment of myelofibrosis.
EP. 12: Considering Toxicities and Side Effects of JAK Inhibitors in Patients with MF
Abdulraheem Yacoub, MD, details the side effect profiles of the approved JAK inhibitors for myelofibrosis treatment.
EP. 13: Symptom Monitoring in Patients with MF
The panel explains the standards for symptom assessment in patients with myelofibrosis and how often patients are monitored.
EP. 14: Exploring the Future of MF Treatment
The panel closes their discussion by highlighting novel agents in the treatment of myeloproliferative neoplasms to look out for.
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