A panel of experts summarizes the current HR+ breast cancer treatment landscape and discusses recent data updates in the field, including those presented at the 2022 San Antonio Breast Cancer Symposium (SABCS).
EP. 1: Incidence and Typical Prognosis of HER2+ Early Breast Cancer
Virginia Borges, MD, explains how common HER2+ early breast cancer is and the goals of treatment for patients.
EP. 2: Neoadjuvant Treatment of HER2+ Early Breast Cancer
A review of the standard of care regimens for the preoperative or neoadjuvant treatment of HER2+ early breast cancer.
EP. 3: De-Escalation Approaches in Patients with HER2+ Early Breast Cancer
Debu Tripathy, MD, details when he utilizes a treatment de-escalation approach in his patients with HER2+ early breast cancer.
EP. 4: Subcutaneous vs Intravenous Pertuzumab/Trastuzumab for Treatment of HER2+ Early Breast Cancer
The panel shares the factors that influence whether they recommend a subcutaneous or intravenous formulation of pertuzumab/trastuzumab in addition to chemotherapy.
EP. 5: Factors Informing Adjuvant Treatment Selection in HER2+ Early Breast Cancer
A look at how patient response to neoadjuvant treatment for HER2+ early breast cancer informs adjuvant treatment selection.
EP. 6: Expert Perspectives on Clinical Experience with Ado-Trastuzumab Emtansine (T-DM1)
The panel explains their clinical experiences with using the antibody-drug conjugate (ADC) ado-trastuzumab emtansine (T-DM1) to treat HER2+ early breast cancer.
EP. 7: Clinical Data Updates on Adjuvant Pertuzumab/Trastuzumab for HER2+ Early Breast Cancer
A review of recently reported data on the use of adjuvant pertuzumab/trastuzumab for the treatment of HER2+ early breast cancer, including data from the APHINITY and PHranceSCa trials.
EP. 8: Extended Adjuvant Neratinib Therapy for Patients with HER2+ Early Breast Cancer
Joyce O’Shaughnessy, MD, starts a conversation on which patients with HER2+ early breast cancer are the best candidates for extended adjuvant neratinib therapy.
EP. 9: Data Updates in Adjuvant HER2+ Early Breast Cancer from SABCS 2022
The panel highlights recent data updates in adjuvant treatment of HER2+ early breast cancer, including longer-term follow-up data from the APT and ATEMPT trials.
EP. 10: HER2+ mBC: First-Line Treatment Regimens
A focused discussion on available options for the first-line treatment of HER2+ metastatic breast cancer (mBC), with reference to data from the CLEOPATRA trial.
EP. 11: Second-Line Treatment of HER2+ mBC and Recent Data Updates
Maryam Lustberg, MD, MPH introduces the standard of care regimens for the second-line treatment of HER2+ metastatic breast cancer, followed by a discussion of recent data on the ADC trastuzumab deruxtecan (T-DXd).
EP. 12: Options for Third- and Further-Line Treatment of HER2+ mBC
Dr Debu Tripathy explains the treatment options for patients with HER2+ metastatic breast cancer in the third-line and later-line settings, including combination tucatinib/trastuzumab/capecitabine.
EP. 13: Use of MRI for Surveillance of Brain Metastases in Patients with HER2+ mBC
The panel discusses the management of patients with HER2+ mBC with asymptomatic brain mets and shares their thoughts on the use of surveillance brain MRI in this setting.
EP. 14: Emerging Data and Investigational Agents in HER2+ mBC
The panel highlights emerging data from SABCS 2022 on investigational agents being explored for HER2+ mBC treatment.
EP. 15: Unmet Needs and the Future of HER2+ Breast Cancer Treatment
The panel closes their discussion by summarizing the most exciting recent advances in HER2+ breast cancer, the future of treatment, and unmet needs that must be addressed.
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