Pembrolizumab/Lenvatinib Combo Misses Survival End Points in Unresectable HCC
August 3rd 2022The addition of pembrolizumab to lenvatinib did not significantly improve overall survival or progression-free survival over lenvatinib alone when used in the frontline treatment of patients with unresectable hepatocellular carcinoma, missing the dual primary end points of the phase 3 LEAP-002 trial.
Novel Biomarker Testing Could Enhance Immunotherapy Treatment Decisions in NSCLC
July 29th 2022PD-L1 and tumor mutational burden are established biomarkers for leveraging immunotherapy in non–small cell lung cancer; however, their use may not be appropriate in determining treatment decisions for all patients.
FDA Defers Action on BLA for Tislelizumab in Second-Line Esophageal Squamous Cell Carcinoma
July 14th 2022The FDA has deferred action on the biologics license application seeking the approval of tislelizumab as a second-line treatment in patients with unresectable or metastatic esophageal squamous cell carcinoma, citing the inability to conduct required inspections in China because of travel restrictions associated with COVID-19.