Dr. Aghajanian on PARP Inhibitors for Ovarian Cancer

Carol Aghajanian, MD, from the Memorial Sloan-Kettering Cancer Center, discusses the treatment of ovarian cancer with PARP inhibitors.

At the 2013 American Society of Clinical Oncology (ASCO) Meeting, Aghajanian anticipated the confirmation of the activity of PARP inhibitors, such as olaparib. Activity is likely to be seen in the most common type of ovarian cancer, high grade serous ovarian cancer.

Though phase I and phase II trials are currently underway, the oncology community is looking forward to the launching of phase III trials in different states of ovarian cancers. Upcoming trials will analyze PARP inhibitors given with and following chemotherapy as well as a maintenance therapy. New trials will also employ biomarkers to determine which groups of patients will benefit most from PARP inhibitors.