Dr. Altman on Neoadjuvant Chemotherapy in High-Grade Serous Carcinoma

Alon Altman, MD, associate professor, Department of Obstertrics, Gynecology and Reproductive Sciences, University of Manitoba, discusses neoadjuvant chemotherapy for patients with high-grade serous ovarian carcinoma.

There were a couple big studies that showed equivalence of neoadjuvant chemotherapy to primary debulking, explains Altman. Across the world, many centers have shifted to more patients receiving neoadjuvant chemotherapy followed by surgery and further chemotherapy.

However, multiple studies have shown that the outcomes for the neoadjuvant group were not as beneficial, but the reasoning is still unknown, states Altman. One of the possible explanations is the number of cycles being administered.