Video

Dr. Braghiroli on Clinical Characteristics of NRAS-Mutant CRC

Maria Ignez Braghiroli, MD, medical oncologist, Instituto do Câncer do Estado de São Paulo, discusses clinical characteristics and outcomes of patients with NRAS-mutant metastatic colorectal cancer (mCRC) during an interview at the 2016 ESMO Congress.

Maria Ignez Braghiroli, MD, medical oncologist, Instituto do Câncer do Estado de São Paulo, discusses clinical characteristics and outcomes of patients with NRAS-mutant metastatic colorectal cancer (mCRC) during an interview at the 2016 ESMO Congress.

NRAS-mutant mCRC is an aggressive subset of mCRC, and patients typically experience worse overall survival than patients with RAS wild-type tumors of KRAS-mutant mCRC.

This subgroup of patients with NRAS-mutant mCRC tend to have increased left-sided colon primary tumors, and these patients may also have a distinct molecular pathogenesis.

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