Video

Dr. Brufsky Discusses the tnAcity Trial in TNBC

Adam Brufsky, MD, PhD, FACP, discusses the tnAcity trial, which is aimed to clarify how best to use existing drugs in patients with triple-negative breast cancer.

Adam Brufsky, MD, PhD, FACP, professor of medicine, associate division chief, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, discusses the tnAcity trial, which is aimed to clarify how best to use existing drugs in patients with triple-negative breast cancer (TNBC).

Brufsky says the idea of the tnAcity trial is that while most physicians use gemcitabine and carboplatin, there is not much evidence to support that that is the optimal form of treatment. This trial will measure the efficacy of combinations, such as gemcitabine and carboplatin, carboplatin and nab-paclitaxel (Abraxane), and gemcitabine and nab-paclitaxel. The phase II trial, which has about 80 patients enrolled, will randomize the patients to receive one of the three combinations.

Based on the results of the phase II trial, Brufsky says, the two combinations that prove to be the most effective will be tested. The phase III portion will begin in about a year. Brufsky says the trial will answer a very important question while also investigating biomarkers that will help physicians figure out how to optimally treat patients with TNBC.

<<<

View more from the 2013 SABCS Meeting

Related Videos
Ruth M. O’Regan, MD
Paolo Caimi, MD
Jennifer Scalici, MD
Steven H. Lin, MD, PhD
Anna Weiss, MD, associate professor, Department of Surgery, Oncology, associate professor, Cancer Center, University of Rochester Medicine
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor, pharmacology, deputy director, Yale Cancer Center; chief, Hematology/Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital; assistant dean, Translational Research, Yale School of Medicine
Victor Moreno, MD, PhD
Benjamin P. Levy, MD, with Kristie Kahl and Andrew Svonavec
Sheldon M. Feldman, MD
Dana Zakalik, MD