Video

Dr. Dietrich on Navigating the NSCLC Treatment Landscape

Martin Dietrich, MD, PhD, shares how he navigates the non–small cell lung cancer (NSCLC) treatment landscape.

Martin Dietrich, MD, PhD, medical oncologist, Florida Cancer Specialists & Research Institute, assistant professor, University of Central Florida, shares how he navigates the non–small cell lung cancer (NSCLC) treatment landscape.

Because the regimens examined in the phase 3 KEYNOTE-189 (NCT02578680) and KEYNOTE-407 (NCT02775435) trials are so broadly applicable, they have shifted focus away from utilizing biomarkers to guide treatment for patients with NSCLC, according to Dietrich. The long-term effect of these regimens remains highly dependent on PD-L1 expression levels, and an incremental benefit is observed the higher the PD-L1 expression is, Dietrich says. In the PD-L1–negative population, single-agent PD-1 inhibitors do not have a lasting effect. As such, for these patients, combination strategies must be explored, Dietrich adds. 

In terms of patients with PD-L1–high disease, the combination of ipilimumab (Yervoy) plus nivolumab (Opdivo) has received regulatory approval, and has been shown to provide an absolute survival benefit of 10% at 4 years compared with nivolumab alone, Dietrich adds. Looking forward, TIGIT antibodies will be integral in enhancing PD-L1–positive expression, Dietrich concludes.

Related Videos
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for lorlatinib in ROS1-positive NSCLC after crizotinib and chemotherapy.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for taletrectinib in ROS1-positive advanced non–small cell lung cancer.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, on progression patterns and subsequent therapies after lorlatinib in ALK-positive NSCLC.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss preclinical CNS data for the ROS1 inhibitor zidesamtinib.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for zidesamtinib in ROS1-positive non–small cell lung cancer.
Yair Lotan, MD, UT Southwestern Medical Center
Alan Tan, MD, Vanderbilt-Ingram Cancer Center
Alex Herrera, MD
Roy S. Herbst, MD, PhD
Sheldon M. Feldman, MD