Video

Dr. Fakih on the Safety Profile of AMG 510 in KRAS G12C-Mutated CRC

Marwan Fakih, MD, discusses the safety profile of AMG 510 in KRAS G12C-mutated colorectal cancer.

Marwan Fakih, MD, professor, Department of Medical Oncology and Therapeutics Research, medical director, Judy and Bernard Briskin Center for Clinical Research, co-director, Gastrointestinal Cancer Program, and section head, Gastrointestinal Medical Oncology, City of Hope, discusses the safety profile of AMG 510 in KRAS G12C-mutated colorectal cancer (CRC).

At the 2020 ASCO Virtual Scientific Program, findings from the phase 1/2 CodeBreak 100 trial demonstrated meaningful clinical activity with AMG 510 in patients with advanced KRAS G12C-mutant CRC.

As AMG 510 is a highly selective KRAS G12C inhibitor that does not substantially bind to wild-type KRAS, limited off-target activity was observed, says Fakih.

Regarding safety, 47.6% of 42 evaluable patients experienced any-grade treatment-related adverse events (TRAEs). The most common TRAEs were diarrhea, fatigue, nausea, blood creatine phosphokinase increase, anemia, and vomiting. Grade 3 TRAEs occurred in 4.8% of patients and no grade 4 TRAEs were observed.

The favorable safety profile noted with AMG 510 suggests the agent may have utility in combination regimens going forward, concludes Fakih.

Related Videos
Michael R. Grunwald, MD, FACP
Peter Forsyth, MD
John N. Allan, MD
Dr Dorritie on the Clinical Implications of the 5-Year Follow-Up Data From CAPTIVATE in CLL/SLL
Minoo Battiwalla, MD, MS
Kathleen N. Moore, MD, MS
Paolo Caimi, MD
Dr Oveisi on the Importance of Patient Counseling Prior to CAR T-Cell Therapy in Myeloma
Leo I. Gordon, MD
Janaki Neela Sharma, MD, University of Miami