Dr. Gertz on Expanding Treatment Options for Myeloma

Morie Gertz, MD, the chair of the Department of Medicine at the Mayo Clinic, discusses expanding treatment options for myeloma.

There are a number of new agents that are being used for the management of myeloma, says Gertz. Daratumumab, a fully human IgG1k monoclonal antibody that targets CD38, has demonstrated promising activity as monotherapy in patients with relapsed/refractory multiple myeloma.

Carfilzomib, lenalidomide, and dexamethasone have been shown to improve progression-free survival. Panobinostat, a deacetylase (DAC) inhibitor is also being used in new ways to treat myeloma.