Dr. Grignani Discusses the Safety Profile of Trabectedin in Sarcoma

Giovanni Grignani, MD, medical oncologist, Candiolo Cancer Institute IRCCS, discusses the safety profile of trabectedin (Yondelis) in the treatment of sarcoma.

The aging population of patients with sarcoma have several comorbidities, which can disrupt the course of treatment. But, in a recent phase II study, trabectedin showed a favorable safety profile with no toxicity related deaths in this population.

This regimen requires very careful premedication with steroids and close follow up, though, says Grignani—as there are patients who might develop unusual toxicities.