Video

Dr. Kahl Discusses the Potential of Frontline Ibrutinib in MCL

Author(s):

Brad Kahl, MD, professor in the Department of Medicine, Washington University School of Medicine in St. Louis, Siteman Cancer Center, discusses the potential of frontline ibrutinib (Imbruvica) in the treatment of patients with mantle cell lymphoma.

Brad Kahl, MD, professor in the Department of Medicine, Washington University School of Medicine in St. Louis, Siteman Cancer Center, discusses the potential of frontline ibrutinib (Imbruvica) in the treatment of patients with mantle cell lymphoma (MCL).

Ibrutinib has been a mainstay in the treatment of patients with relapsed/refractory MCL since its FDA approval in 2013. Currently, ibrutinib is being investigated as a first-line treatment for patients with MCL in the large phase III SHINE trial (NCT01776840). The trial is evaluating the safety and efficacy of ibrutinib plus bendamustine and rituximab (Rituxan) in older patients with newly-diagnosed MCL who are not eligible for stem cell transplant. Patients are being randomized to either bendamustine and rituximab plus ibrutinib or bendamustine and rituximab plus placebo.

SHINE has fully enrolled, but no data are available yet. Kahl says that if the trial is positive, it has the potential to change the standard of care for the frontline treatment of older patients with MCL. The trial is expected to read out in 2021.

Related Videos
Tiago Biachi, MD, PhD
Dr Girard on De Novo and Acquired Resistance Alterations in HER2-Altered NSCLC
Elias Jabbour, MD
Daniel DeAngelo, MD, PhD
Douglas W. Sborov, MD, MS
Meletios (Thanos) Dimopoulos, MD, professor, therapeutics, Hematology Oncology, National and Kapodistrian University of Athens School of Medicine
Adam E. Singer, MD, PhD, Health Sciences Clinical Instructor, medicine, division lead, kidney cancer, Division of Hematology/Oncology, UCLA Health
Ami Umesh Badami, MD
Premal Thaker, MD, MS
Paul Chinfai Lee, MD, discusses the role of surgeons in regard to molecular testing in non–small cell lung cancer.