Video

Dr. Kim Discusses the Primary Efficacy Results From the B-F1RST Trial in NSCLC

Edward S. Kim, MD, chair, Department of Solid Tumor Oncology, Levine Cancer Institute, discusses the primary efficacy results from the B-F1RST trial in non–small cell lung cancer (NSCLC).

Edward S. Kim, MD, chair, Department of Solid Tumor Oncology, Levine Cancer Institute, discusses the primary efficacy results from the B-F1RST trial in non—small cell lung cancer (NSCLC).

B-F1RST is a single-arm trial assessing a novel blood-based tumor mutational burden (TMB) marker in patients with NSCLC who are receiving single-agent atezolizumab (Tecentriq) in the frontline setting. TMB is an important and emerging area in the use of checkpoint inhibitor therapy, Kim says. PD-L1 is used as a biomarker for checkpoint inhibitor therapy right now, and while it has clinical utility, many feel that there is room for more biomarkers. A blood-based TMB marker was explored in this trial.

Patients were treated with atezolizumab until progression or lack of clinical benefit. TMB was assessed at baseline. The blood that was submitted had to have a minimum amount of tumor cell content in order for those patients to be evaluated, Kim explains.

Related Videos
Benjamin P. Levy, MD, with Kristie Kahl and Andrew Svonavec
Noman Ashraf, MD
Ivy Riano, MD, of Dartmouth Geisel School of Medicine
Daniel E. Haggstrom, MD
Daniel E. Haggstrom, MD
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss unmet needs and future research directions in ALK-positive and ROS1-positive NSCLC.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for lorlatinib in ROS1-positive NSCLC after crizotinib and chemotherapy.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss data for taletrectinib in ROS1-positive advanced non–small cell lung cancer.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, on progression patterns and subsequent therapies after lorlatinib in ALK-positive NSCLC.
Gregory J. Riely, MD, PhD, and Benjamin Besse, MD, discuss preclinical CNS data for the ROS1 inhibitor zidesamtinib.