Video

Dr. Kimmick on the Results of the ATEMPT Trial in Early-Stage HER2+ Breast Cancer

Gretchen G. Kimmick, MD, MS, discusses the results of the phase 2 ATEMPT trial in early-stage HER2-positive breast cancer

Gretchen G. Kimmick, MD, MS, professor of medicine, Duke University School of Medicine, ​member, Duke Cancer Institute, discusses the results of the phase 2 ATEMPT (NCT01853748) trial in early-stage HER2-positive breast cancer.

The ATEMPT trial randomized patients with stage I HER2-positive breast cancer to ado-trastuzumab emtansine (T-DM1; Kadcyla) vs adjuvant paclitaxel plus trastuzumab (Herceptin; TH). Patients’ tumors were less than 2 centimeters and did not involve lymph nodes or only had micrometastasesin the lymph nodes, Kimmick explains.

The disease-free survival results of the trial were in favor of T-DM1, which offered another option for patients with early-stage breast cancer, Kimmick continues. However, clinically relevant toxicities were not decreased with T-DM1 vs TH; 17% of patients receiving T-DM1 discontinued before completion of treatment compared with 6% of patients with TH. Although T-DM1 could be considered as a therapeutic option for patients with early-stage HER2-positive breast cancer, data are needed to determine the clinical implications of early treatment discontinuation with the agent, Kimmick concludes.

Related Videos
J. Bradley Elder, MD
Rimas V. Lukas, MD
Shubham Pant, MD, MBBS
Brett L. Ecker, MD
Benjamin Garmezy, MD, assistant director, Genitourinary Research, Sarah Cannon Research Institute
Howard S. Hochster, MD, FACP,
John H. Strickler, MD
Brandon G. Smaglo, MD, FACP
Cedric Pobel, MD
Ruth M. O’Regan, MD