Video
Author(s):
Rami S. Komrokji, MD, clinical director, Department of Malignant Hematology, H. Lee Moffitt Cancer Center, discusses a study that examined risk stratification of therapy-related MDS.
Rami S. Komrokji, MD, clinical director, Department of Malignant Hematology, H. Lee Moffitt Cancer Center, discusses a study that examined risk stratification of therapy-related MDS.
Komrokji said for the study, 370 patients with therapy-related MDS were compared to a cohort of patients with de novo MDS. Half of the patients with therapy-related MDS had solid tumors and the majority were treated with chemotherapy for their prior disease. The results showed that most of the clinical models do predict the outcome of these patients.
From this study, researchers found that if you take a patient with de novo MDS and compare them stage-by-stage with therapy-related MDS, patients with therapy-related MDS always do worse, even if the disease is classified as low-risk therapy-related MDS, Komrokji says. However, there is a subset of patients whose survival can be measured in years. These patients could be treated stepwise as opposed to treating them as high-risk, Komrokji says.
The results found that the revised IPSS and the Global MD Anderson Model were the best models to estimate outcome in therapy-related MDS patients. Komrokji says the next step to risk stratifying these patients would be integrating the molecular mutations in patients with therapy-related MDS.
<<<
Observation Is a Reasonable Alternative to Adjuvant PD-1 Blockade in Stage IIB/IIIC Melanoma
Dr Oluwole on CRS and Neurotoxicity Beyond 2 Weeks After Axi-Cel Infusion in R/R LBCL
Dr Garfall on Ide-Cel and Lenalidomide Maintenance in Myeloma After Suboptimal ASCT Response
Piflufolastat F18 Imaging Is Associated With High Clinician Confidence in Prostate Cancer Management
Strategic and Safe Lorlatinib Use Is Key to Optimal ALK+ NSCLC Management
TERZO Trial Seeks to Validate Duvelisib as an Effective Targeted Treatment in TFH Nodal T-Cell Lymphoma
Mevrometostat Plus Enzalutamide Improves rPFS vs Enzalutamide in Metastatic CRPC
Kimberly Stegmaier Named as Pediatric Oncology Chair at Dana-Farber
2 Commerce Drive
Cranbury, NJ 08512