Video

Dr. Mahoney on Potential of VISTA-Targeting Therapy in RCC

Kathleen Mahoney, MD, PhD, discusses the potential of targeting V-domain immunoglobulin containing suppressor of T-cell activation in renal cell carcinoma.

Kathleen Mahoney, MD, PhD, instructor of medicine, Harvard Medical School, attending physician of medicine, Beth Israel Deaconess Medical Center, discusses the potential benefit of targeting V-domain immunoglobulin containing suppressor of T-cell activation (VISTA) in renal cell carcinoma (RCC).

VISTA, a B7 protein, is in the same family as PD-1 and PD-L1 and is overexpressed in many kidney cancers including clear cell, papillary and chromophobe RCC, explains Mahoney. Early data suggest that VISTA may be a potentially actionable target that may have immunosuppressive functions in kidney cancer and other cancers.

With a better understanding of the biology of VISTA, investigators may be able to develop effective therapeutics to treat patients with kidney cancer, says Mahoney. The main questions to answer, she adds, is how to best select patients and minimize toxicity while developing effective therapies for these patients. A stronger understanding of the biology of this potential target may provide that insight, Mahoney concludes.

Related Videos
Tiago Biachi, MD, PhD
Dr Girard on De Novo and Acquired Resistance Alterations in HER2-Altered NSCLC
Elias Jabbour, MD
Daniel DeAngelo, MD, PhD
Douglas W. Sborov, MD, MS
Meletios (Thanos) Dimopoulos, MD, professor, therapeutics, Hematology Oncology, National and Kapodistrian University of Athens School of Medicine
Adam E. Singer, MD, PhD, Health Sciences Clinical Instructor, medicine, division lead, kidney cancer, Division of Hematology/Oncology, UCLA Health
Ami Umesh Badami, MD
Premal Thaker, MD, MS
Paul Chinfai Lee, MD, discusses the role of surgeons in regard to molecular testing in non–small cell lung cancer.