Video

Dr. Massarelli Discusses Frontline Immunotherapy in NSCLC

Erminia Massarelli, MD, PhD, MS, discusses advances in front-line immunotherapy in non–small cell lung cancer.

Erminia Massarelli, MD, PhD, MS, co-director of the Lung Cancer and Thoracic Oncology Program, section chief of Thoracic Oncology, and associate professor in the Department of Medical Oncology and Therapeutics Research at City of Hope, discusses advances in frontline immunotherapy in non–small cell lung cancer (NSCLC).

Many novel immunotherapy combinations are emerging, such as those combining anti-TIGIT antibodies and LAG-3 inhibitors, Massarelli says. One combination currently being studied is that of an anti-TIGIT antibody and checkpoint inhibitor, which has shown promise in patients with PD-L1 levels of 50% or higher, Massarelli explains.

Other clinical trials studying immunotherapy include those looking at cell therapy in NSCLC, Massarelli notes. Combinations of immuno-oncology molecules with TKIs such as lenvatinib (Lenvima) are also promising, Massarelli concludes.

Related Videos
Funda Meric-Bernstam, MD
Bhavana Pothuri, MD
Kristen Spencer, DO
Laurence Albigès, MD, PhD
Nirav Shah, MD, MSHP, discusses evaluating zamtocabtagene autoleucel in patients with relapsed/refractory diffuse large B-cell lymphoma.
Bhagirathbhai Dholaria, MBBS
Sairah Ahmed, M.D
Joshua K. Sabari, MD
Barry W. Goy, MD
Fred Saad, CQ, MD, FRCS, FCAHS, director, Prostate Cancer Research, Montreal Cancer Institute, Centre Hospitalier de l’Université de Montréal; full professor, Department of Surgery, Université de Montréal; uro-oncologist, Urology Department, University of Montreal Health Center