Dr. McDermott on IMmotion150 Trial in RCC

David F. McDermott, MD, Beth Israel Deaconess Medical Center, discusses the recent IMmotion150 trial in Renal Cell Carcinoma (RCC).

IMmotion150, a phase II, open-label, randomized study of atezolizumab (Tecentriq) in combination with bevacizumab (Avastin) versus sunitinib (Sutent) in patients with untreated advanced RCC, is the first large look at PD-L1 blockade with atezolizumab in patients with untreated advanced RCC, according to McDermott.

This trial address the question of whether adding VEGF blockade with bevacizumab to PD-L1 blockade with atezolizumab extends benefit. The answer seems to be, “Yes,” says McDermott, as survival outcomes did improve, particularly in the subset of patients with inflamed tumors.