Video

Dr. Mian on the Investigation into the Synchronous Up-front Setting of Metastatic Prostate Cancer

Omar Mian, MD, PhD, discusses the ongoing investigation into the synchronous up-front setting of metastatic prostate cancer.

Omar Mian, MD, PhD, radiation oncologist, physician/scientist, associate staff, Taussig Cancer Institute, Cleveland Clinic, discusses the ongoing investigation into the synchronous up-frontsetting of metastatic prostate cancer.

There are a lack of data on the clinical benefit of metastasis-directed regimens, creating an unmet medical need, Mian says. However, ongoing research is evaluating intensified hormone therapies, such as GnRH agonists and selective androgen receptor modulators, Mian explains. Radiation at several secondary tumor sites in addition to the prostate is also being investigated, Mian adds.

The phase 2/3 STAMPEDE trial (NCT00268476) has opened new investigational arms evaluating treatment with abiraterone acetate (Zytiga) and radiotherapy, respectively, Mian continues. Additionally, several prospective clinical trials are investigating the use of radiation therapy for nodal recurrences within prostate cancer. Until more data can be collected, clinicians should be selective in their use of ablative radiation as an induction therapy, Mian concludes.

Related Videos
Timothy Gershon, MD, PhD
Jordan Hansford, MD
James J. Harding, MD, associate attending physician, Memorial Sloan Kettering Cancer Center
J. Bradley Elder, MD
Rimas V. Lukas, MD
Adam E. Singer, MD, PhD, Health Sciences Clinical Instructor, medicine, division lead, kidney cancer, Division of Hematology/Oncology, UCLA Health
Diane Reidy-Lagunes, MD, vice chair, Oncology Operations, Regional Care Network, Memorial Sloan Kettering Cancer Center
Shubham Pant, MD, MBBS
Kevin Kalinsky, MD, MS, professor, Department of Hematology and Medical Oncology, director, Division of Medical Oncology, Department of Hematology and Medical Oncology, Emory University School of Medicine; Louisa and Rand Glenn Family Chair in Breast Cancer Research, director, Glenn Family Breast Center, director, Breast Medical Oncology, Winship Cancer Institute of Emory University
Brett L. Ecker, MD