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Dr. O’Malley on the Utility of Chemoimmunotherapy in Ovarian Cancer

David M. O'Malley, MD discusses the utility of chemoimmunotherapy in ovarian cancer.

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    David M. O'Malley, MD, professor, Department of Obstetrics and Gynecology, The Ohio State University (OSU) College of Medicine, director, Division of Gynecologic Oncology and Clinical Research in Gynecologic Oncology, co-director, Gynecologic Oncology Phase I Program, The OSU Comprehensive Cancer Center–James, discusses the utility of chemoimmunotherapy in ovarian cancer.

    The largest trial in ovarian cancer that evaluated a chemoimmunotherapeutic strategy wasthe phase 3 JAVELIN OVARIAN 100 trial (NCT02718417), O’Malley explains. The 3-arm study randomized patients with previously untreated epithelial ovarian cancer to receive chemotherapy with or without avelumab (Bavencio) followed by avelumab maintenance vs chemotherapy alone; however, the results of the study proved to be underwhelming, O’Malley says.

    Moreover, the treatment arms behaved very similarly, and in the intent-to-treat population, patients who received chemotherapy alone had improved progression-free survival compared with those who received either of the avelumab-based regimens, O’Malley continues. A subgroup analysis revealed that patients with PD-L1–positive disease did not derive additional benefit from the immunotherapy-containing approaches compared with patients who were PD-L1 negative, O’Malley concludes. 

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