Video

Dr. Oliveira on the Examination of Camizestrant Vs Fulvestrant in ER+/HER2- Breast Cancer

Mafalda Oliveira, MD, PhD, discusses the examination of camizestrant vs fulvestrant in estrogen receptor-positive, HER2-negative advanced breast cancer.

Mafalda Oliveira, MD, PhD, attending physician, Medical Oncology Department, Breast Cancer Group, Vall d'Hebron University Hospital, discusses the examination of camizestrant (formerly AZD9833) vs fulvestrant (Faslodex) in estrogen receptor (ER)–positive, HER2-negative advanced breast cancer.

At the 2022 San Antonio Breast Cancer Symposium, data from the phase 2 SERENA-2 trial (NCT04214288) were presented, comparing the efficacy and safety of camizestrant vs fulvestrant in patients with ER-positive, HER2-negative breast cancer. The phase 2 trial formally evaluated 2 differentdoses of camizestrant: 75 mg and 150 mg, Oliveira explains.

When treating patients with 75 mg of camizestrant, the hazard ratio (HR) was 0.58 with a median progression-free survival (PFS) of 7.2 months vs 3.7 months in patients treated with fulvestrant, Oliveira says. Moreover, in patients treated with 150 mg of camizestrant, the HR was 0.67, with a median PFS of 7.7 months. Both doses of camizestrant led to a statistically significant improvement in PFS compared with fulvestrant, which induced a median PFS of 3.7 months, Oliveira explains. The trial was not designed to compare the 2 doses of camizestrant, Oliveira concludes.

Related Videos
Jennifer Scalici, MD
Steven H. Lin, MD, PhD
Anna Weiss, MD, associate professor, Department of Surgery, Oncology, associate professor, Cancer Center, University of Rochester Medicine
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor, pharmacology, deputy director, Yale Cancer Center; chief, Hematology/Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital; assistant dean, Translational Research, Yale School of Medicine
Victor Moreno, MD, PhD
Tiago Biachi, MD, PhD
Dr Girard on De Novo and Acquired Resistance Alterations in HER2-Altered NSCLC
Elias Jabbour, MD
Daniel DeAngelo, MD, PhD
Douglas W. Sborov, MD, MS