Video

Dr Peffault de Latour on the Benefit of Iptacopan Vs SOC in PNH and Residual Anemia

Regis Peffault de Latour, MD, PhD, discusses the benefit observed with iptacopan vs standard-of-care eculizumab or ravulizumab in patients with paroxysmal nocturnal hemoglobinuria and residual anemia during the phase 3 APPLY-PNH trial.

Regis Peffault de Latour, MD, PhD, professor of hematology, Hematology and Bone Marrow Transplant Department of the Saint-Louis Hospital, Hôpital Saint Louis, in Paris, France, discusses the benefit observed with iptacopan vs standard-of-care eculizumab (Soliris) or ravulizumab (Ultomiris) in patients with paroxysmal nocturnal hemoglobinuria (PNH) and residual anemia during the phase 3 APPLY-PNH trial (NCT04558918).

Data from the study were presented during the 2022 ASH Annual Meeting. The trial met both co-primary end points for the percentage of patients with an increase in hemoglobin levels of at least 2 g/dL and at least 12 g/dL in the absence of red blood cell transfusions, Peffault de Latour says.

Fifty-one of 60 patients treated with iptacopan experienced a hemoglobin increase of at least 2 g/dL compared with 0 of 35 patients treated with SOC. Additionally, 42 of 60 patients in the iptacopan arm achieved a hemoglobin increase of at least 12 g/dL vs none in the SOC arm, Peffault de Latour concludes.

Related Videos
Daniel DeAngelo, MD, PhD
Marc J. Braunstein, MD, PhD, associate professor, Department of Medicine, co-director, Hematology-Oncology System, New York University (NYU) Grossman Long Island School of Medicine
Douglas W. Sborov, MD, MS, associate professor, Department of Internal Medicine—Division of Hematology and Hematologic Malignancies; director, Hematology Disease Center and Plasma Cell Dyscrasias Program, the University of Utah Huntsman Cancer Institute
Bradley C. Carthon, MD, PhD
David C. Fisher, MD
Alan Tan, MD
Binod Dhakal, MD
Sheldon M. Feldman, MD
Yair Lotan, MD, UT Southwestern Medical Center
Alan Tan, MD, Vanderbilt-Ingram Cancer Center