Video

Dr. Raftopoulos on Pulmonary Toxicity With EGFR TKIs

Haralambos Raftopoulos, MD, associate professor, Hofstra North Shore-LIJ School of Medicine, discusses pulmonary toxicity with EGFR tyrosine kinase inhibitors (TKIs).

Haralambos Raftopoulos, MD, associate professor, Hofstra North Shore-LIJ School of Medicine, discusses pulmonary toxicity with EGFR tyrosine kinase inhibitors (TKIs).

To date, researchers and oncologists know most about the EGFR TKIs erlotinib and gefitinib in the context of interstitial lung disease or pulmonary infiltration.

In a large meta-analysis, 1-2% of patients developed some form of interstitial lung disease, ranging from asymptomatic to highly symptomatic. Deaths were most commonly observed in patients who had preexisting lung conditions.

In the initial evaluation of erlotinib and gefitinib, it was hypothesized that combining either agent with gemcitabine-cisplatin would create additive toxicity. In fact, Raftopoulos says, patients who received EGFR TKIs experienced lower incidences of dyspnea and pulmonary toxicity compared with placebo and chemotherapy.

Pulmonary toxicity may have components driven by EGFR in some instances. It may be that EGFR inhibitors may be helping in these situations but contributing to pulmonary toxicity by a different mechanism.

<<<

View more from the 2014 MASCC/ISOO Symposium

Related Videos
Cedric Pobel, MD
Paolo Caimi, MD
Jennifer Scalici, MD
Steven H. Lin, MD, PhD
Anna Weiss, MD, associate professor, Department of Surgery, Oncology, associate professor, Cancer Center, University of Rochester Medicine
Roy S. Herbst, MD, PhD, Ensign Professor of Medicine (Medical Oncology), professor, pharmacology, deputy director, Yale Cancer Center; chief, Hematology/Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital; assistant dean, Translational Research, Yale School of Medicine
Victor Moreno, MD, PhD
Haley M. Hill, PA-C, discusses the role of multidisciplinary management in NRG1-positive non–small cell lung cancer and pancreatic cancer.
Haley M. Hill, PA-C, discusses preliminary data for zenocutuzumab in NRG1 fusion–positive non–small cell lung cancer and pancreatic cancer.
Haley M. Hill, PA-C, discusses how physician assistants aid in treatment planning for NRG1-positive non–small cell lung cancer and pancreatic cancer.