Dr. Tewari on the Hallmarks of Cancer in Black Men With Prostate Cancer

Ashutosh K. Tewari, MD, chairman, Milton and Carroll Petrie Department of Urology, Icahn School of Medicine, director, Department of Urology, Mount Sinai, discusses the hallmarks of cancer among Black men with prostate cancer.

Cancer cells can overcome normal growth control mechanisms and demonstrate constitutive proliferation, Tewari explains. Although all prostate cancer cells do this, the mechanisms by which cells overcome normal growth mechanisms may differ between racial groups, Tewari says.

Similarly, other hallmarks of cancer, such as invasive disease properties, metabolic reprogramming, and metastasis, may vary between Black men and other racial groups, Tewari explains. Tumor energy management is also different because Black men with prostate cancer may have more vessel–dense tumors with inflammation, which can result in aggressive cancers, concludes Tewari.