Video
Author(s):
Srdan Verstovsek, MD, PhD, discusses the rationale for utilizing ruxolitinib and navitoclax in patients with relapsed/refractory myelofibrosis.
Srdan Verstovsek, MD, PhD, the United Energy Resources, Inc. Professor of Medicine, director of the Hanns A. Pielenz Clinical Research Center for Myeloproliferative Neoplasms, and chief of the Section for Myeloproliferative Neoplasms in the Department of Leukemia of the Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center, discusses the rationale for utilizing ruxolitinib (Jakafi) and navitoclax in patients with relapsed/refractory myelofibrosis.
The combination of ruxolitinib and navitoclax is an interesting concept because in myelofibrosis, the majority of patients will experience benefit from ruxolitinib, Verstovsek says. For example, 97.1% of patients in the phase 3 COMFORT-II study (NCT00934544) achieved at least a 35% reduction in splenic volume after being treated with the agent, he explains. However, it is different when an analysis specifically focuses responders because certain thresholds must be met, such as a 35% reduction in spleen volume or a certain reduction in symptoms, Verstovsek says.
While most patients benefit, a certain population of patients only experience a suboptimal response or do not experience a long duration of response, leaving room for improvement, Verstovsek concludes.
DK210 (EGFR) Induces Immune Response Without Increased CRS or Regulatory T Cells in Solid Tumors
Siglec-15 Represents Potential Therapeutic Target in NSCLC, Other Solid Tumors
Radiomic Biomarkers Predict Response in Lung and Liver Uveal Melanoma Metastases
BT7480 Shows Preliminary Activity in Nectin-4+, CD137+ Tumors
2 Commerce Drive
Cranbury, NJ 08512