Dr. Vose on Future Research Efforts With CAR T-Cell Therapy in Lymphoma

Julie M. Vose, MD, MBA, Neumann M. and Mildred E. Harris Professor, chief, Division of Oncology and Hematology, Department of Internal Medicine, University of Nebraska Medical Center, discusses future research efforts with CAR T-cell therapy in lymphoma.

Ongoing clinical trials are evaluating CAR T-cell therapies, as well as other types of treatment, for patients with lymphoma, Vose says. Moreover, some studies are investigating different designs of CAR T-cell therapies, utilizing CAR T-cell therapy in various subtypes of lymphoma, and potentially incorporating the cellular therapy into earlier lines of treatment, Vose says.These efforts may yield opportunities to decrease CAR T-cell therapy­–related toxicities for patients, Vose explains.

Additionally, research efforts are evaluating whether combination regimens with CAR T-cell therapies and other agents, such as BTK inhibitors, are feasible for patients with lymphoma, Vose says. It may also be possible to utilize pre- and post-CAR T-cell therapy radiation to try to enhance efficacy, Vose continues. Additionally, evaluating different types of monoclonalantibodies, bispecific antibodies, or other new agents alone or in combination with CAR T-cell therapy could lend future treatment options for patients, Vose concludes.