FDA Approval Insights: Liso-Cel in Second-Line Relapsed/Refractory LBCL

Welcome to OncLive On Air^®! I’m your host today, Caroline Seymour.

OncLive On Air^® is a podcast from OncLive^®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive^® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, sponsored byBristol Myers Squibb, we spoke with Nilanjan Ghosh, MD, PhD, to discuss the FDA approval of lisocabtagene maraleucel (liso-cel; Breyanzi). Ghosh is the director of the Lymphoma Program at the Levine Cancer Institute of Atrium Health.

On June 24, 2022, the FDA approved liso-cel as second-line therapy for adult patients with large B-cell lymphoma (LBCL), including diffuse large B-cell lymphoma (DLBCL) not otherwise specified (including DLBCL arising from indolent lymphoma), high-grade B-cell lymphoma, primary mediastinal LBCL, and follicular lymphoma grade 3B.

The approval provides patients with earlier access to life-prolonging therapy, particularly those who are older and have comorbidities, Ghosh explained.

In our exclusive interview, Ghosh discussed the FDA approval of liso-cel in LBCL, pivotal efficacy and safety data from the phase 3 TRANSFORM trial (NCT03575351) and the phase 2 TRANSCEND-PILOT-017006 study (NCT03483103), and the effect of the approval on academic and community center practice patterns.

That’s all we have for today! Thank you for listening to this episode of OncLive On Air^®, sponsored by Bristol Myers Squibb. Check back on Mondays and Thursdays for exclusive interviews with leading experts in the oncology field.

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