FDA Approval Insights: Olaparib Plus Abiraterone in BRCA-Mutated mCRPC

Welcome to OncLive On Air^®! I’m your host today, Ashling Wahner.

OncLive On Air^® is a podcast from OncLive^®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive^® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we had the pleasure of speaking with Andrew J. Armstrong, MD, MSc, about the FDA approval of olaparib (Lynparza) plus abiraterone in patients with BRCA-mutated metastatic castration-resistant prostate cancer (mCRPC). Armstrong is a professor of medicine, a professor in surgery, and a professor of pharmacology and cancer biology, as well as a member of the Duke Cancer Institute in Durham, North Carolina.

On May 31, 2023, the FDA approved olaparib plus abiraterone and prednisone or prednisolone in patients with mCRPC harboring deleterious or suspected deleterious BRCA mutations. This regulatory decision was backed by findings from the phase 3 PROpel trial (NCT03732820), in which the median radiographic progression-free survival was not reached in patients with BRCA mutations who received the olaparib combination vs 8 months in those with BRCA mutations who received placebo plus abiraterone.

In our exclusive interview, Dr Armstrong discussed the significance of this approval, key efficacy and safety data from PROpel, and where the field of prostate cancer research may be headed in the future.

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