Video

KEYNOTE-224: Improving HCC Outcomes With Pembrolizumab

Transcript:

Ghassan Abou-Alfa, MD: We’re in San Francisco at the ASCO GI Symposium, and it’s an incredible meeting because quite a bit on liver cancer, or HCC, is going to be presented. As you probably already know, Dr. Zhu from Massachusetts General Hospital reported on the KEYNOTE-224 study, which looked into pembrolizumab in the second-line setting based on a phase II trial.

As I mentioned about nivolumab, there has been a clear response rate that’s evident in regard to pembrolizumab, which is in the 15%-plus range, and was a favored outcome in regard to progression free survival, PFS, and overall survival, OS. But understand we are at least within the context of the phase II data. The response rate is probably what you are after. By all means, this is a nice positive outcome study that might provide an opportunity for further options in regard to the checkpoint inhibitors.

Transcript Edited for Clarity

Brought to you in part by Eisai

Related Videos
Mohammed Najeeb Al Hallak, MD, MS, and Sakti Chakrabarti, MD, discuss ongoing research in gastrointestinal cancers.
Mohammed Najeeb Al Hallak, MD, MS, and Sakti Chakrabarti, MD, discuss research building upon approved combinations in unresectable hepatocellular carcinoma.
Mohammed Najeeb Al Hallak, MD, MS, and Sakti Chakrabarti, MD, on trastuzumab deruxtecan–based regimens in advanced HER2-positive GI cancers.
Mohammed Najeeb Al Hallak, MD, MS, and Sakti Chakrabarti, MD, on tremelimumab/durvalumab vs atezolizumab/bevacizumab in unresectable HCC.
Mohammed Najeeb Al Hallak, MD, MS, and Sakti Chakrabarti, MD, on 5-year data for tremelimumab plus durvalumab in unresectable HCC.
Tanios Bekaii-Saab, MD, FACP
Michel Ducreux, MD, PhD, head, Gastrointestinal Oncology Unit, head, Gastrointestinal Oncology Tumor Board, Gustave Roussy; professor, oncology, Paris-Saclay University
Piotr Rutkowski, MD
Yelena Y. Janjigian, MD
Zhi Peng, MD