Milhem Talks Mechanism of Action, Delivery Methodology, and Ongoing Trials With RP1

Welcome to OncLiveOn Air^®! I’m your host today, Jessica Hergert.

OncLiveOn Air^® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, sponsored by Replimune, we had the pleasure of speaking with Mohammed Milhem, MBBS, the Holden Chair of Experimental Therapeutics, associate director of clinical research and director of the Melanoma Program, Holden Comprehensive Cancer Center, director of the Division of Hematology, Oncology, and Blood & Marrow Transplantation, and a clinical professor at the University of Iowa Hospitals & Clinics, to discuss the unique elements of oncolytic vaccines in oncology and ongoing research with vusolimogeneoderparepvec (RP1) in melanoma and other solid tumors.

Oncolytic vaccines, such as RP1 have generated significant excitement throughout oncology, explained Milhem, citing the ease of administration, mild toxicity profile, and fast-onset responses as distinguishing features of this class of agents for patients who develop progressive disease on standard frontline therapy with PD-1 inhibitors.

In our exclusive interview, Milhem discussed the unique mechanism of action and delivery method of RP1, which is being evaluated in the IGNYTE trial (NCT03767348) for patients with solid tumors, as well as the parallel studies ARTACUS (NCT04349436) and CERPASS (NCT04050436), which are further exploring the agent.

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