Research Reflections: Tarantino Tackles the Implications of ASCO 2022 Data in Breast Cancer

Welcome to OncLive On Air^®! I’m your host today, Caroline Seymour.

OncLive On Air^® is a podcast from OncLive^®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive^® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, we welcomed back Paolo Tarantino, MD, a researcher at the European Institute of Oncology in Milan, Italy, and a clinical research fellow at Dana-Farber Cancer Institute in Boston, Massachusetts.

In our exclusive interview, Tarantino discussed practice-changing findings in breast cancer that were presented at the 2022 ASCO Annual Meeting. He highlighted data from the phase 3 DESTINY-Breast04 trial (NCT03734029), in which fam-trastuzumab deruxtecan-nxki (Enhertu) elicited a median progression-free survival (PFS) of 10.1 months vs 5.4 months with physician’s choice of chemotherapy in patients with hormone receptor (HR)–positive, HER2-low metastatic breast cancer.

Tarantino also spoke about the results of the phase 3 TROPiCS-02 trial (NCT03901339), which showed promising results with sacituzumab govitecan-hziy (Trodelvy) in heavily pretreated patients with HR-positive, HER2-negative metastatic breast cancer. He emphasized the ways in which these positive studies can improve the breast cancer treatment paradigm going forward.

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