Stereotactic Ablative Radiation Slows Progression in Oligometastatic Prostate Cancer

Phuoc Tran, MD, PhD, professor of radiation oncology and molecular radiation sciences at the Johns Hopkins University School of Medicine and a member of the Johns Hopkins Kimmel Cancer Center

Phuoc Tran, MD, PhD

Stereotactic ablative radiation (SABR) reduced disease progression compared with observation in patients with oligometastatic prostate cancer, according to findings from the phase II ORIOLE study published in JAMA Oncology.^1,2

In the SABR arm, progression at 6 months occurred in 19% (n = 7) of 36 patients compared with 61% (11 of 18) in the observation arm (P = .005). The median progression-free survival was not reached versus 5.8 months, respectively (HR, 0.30; 95% CI, 0.11-0.81; P = .002). Additionally, the investigations observed that total consolidation of PSMA radiotracer-avid disease decreased the risk of new lesions at 6 months (16% vs 63%; P = .006).

An analysis of patients’ white blood cells found a link between SABR and an increased number of T cells. The investigators saw this as potential evidence that the radiation therapy had triggered a full-body immune system response to the patient’s tumors.

“It has been a longstanding question, especially important now in the era of immunotherapy, whether any type of radiation, and SABR specifically, can stimulate the immune system,” study leader Phuoc Tran, MD, PhD, professor of radiation oncology and molecular radiation sciences at the Johns Hopkins University School of Medicine and a member of the Johns Hopkins Kimmel Cancer Center, said in a press release. “Our trial offers the best data to date to suggest that SABR can cause a systemic immune response.”

Oligometastatic tumors are defined as those that have metastasized to 1 to 3 sites within the body. The phase II ORIOLE trial randomized 54 men with oligometastatic prostate cancer in a 2:1 ratio to SABR (n = 36) or observation (n = 18). Patients were accrued between March 2018 and May 2019 from 3 radiation treatment facilities in the United States affiliated with a university hospital.

Patient characteristics were well balanced at baseline. Overall, the median age was 68 years, 56% of patients had R0 disease, and 28% of patients had R1 disease. As initial management, 83% of patients had surgery and 17% had radiotherapy. The median time to first recurrence was 22 months.

Forty-two percent of patients in the SABR arm had prior androgen-deprivation therapy (ADT), compared with 28% in the control arm. The median PSA at baseline was 6 ng/dL (range, 2-13) and 7 ng/dL (range, 3-17), respectively, and the median PSA doubling time was 8 months (range, 4-11) versus 6 months (range, 4-11), respectively.

The primary endpoint of the study was progression at 6 months by PSA level increase, progression detected by conventional imaging, symptomatic progression, ADT initiation for any reason, or death.

In their article, the authors also noted that, “T-cell receptor sequencing identified significant increased clonotypic expansion following SABR and correlation between baseline clonality and progression with SABR only (0.082085 vs 0.026051; P = .03).”

There were no grade ≥3 adverse events reported.

Tran and his team are also exploring SABR in the RAVENS trial (NCT04037358), which is combining SABR with radium-223 (Xofigo) in patients with oligometastatic prostate cancer.

References

1. Intense Form of Radiation Slows Disease Progression in Some Men with Prostate Cancer That Has Spread. Published online March 26, 2020. https://bit.ly/3bA0xBN. Accessed March 27, 2020.
2. Phillips R, Shi WY; Deek M, et al. Outcomes of observation vs stereotactic ablative radiation for oligometastatic prostate cancer: the ORIOLE phase 2 randomized clinical trial [published online March 26, 2020]. JAMA Oncol. doi:10.1001/jamaoncol.2020.0147