Dr. Adams on Tackling Storage and Logistical Challenges in Cell Therapy

Julian Adams, PhD, chief executive officer, Gamida Cell, discusses research efforts surrounding GDA-201, including details of the cryo buffer that the company developed in order to efficiently freeze and recover the GDA-201 cells, and also discussed the company’s future studies of omidubicel (Nicord) for the treatment of hematological malignancies.

While cell therapy strategies can be an effective treatment for relapsed or refractory lymphomas, there is still much to be improved when it comes to the production and logistics associated with these therapies. One such company focused on these improvements is Gamida Cell, who recently instituted a new process to improve the stability of 1 of their investigational agents, GDA-201, for the treatment of follicular and diffuse large B cell lymphomas.

Results from a phase 3 study of omidubicel (NCT02730299) recently presented at the Virtual 47th Annual Meeting of the European Society for Blood and Marrow Transplantation showed that the treatment was associated with a significantly improved median time to neutrophil engraftment compared with standard umbilical cord blood transplantation in patients with high-risk hematologic malignancies.