Adjuvant HER2+ Breast Cancer Care Evolves, But Questions Remain
October 9th 2015Mohammad Jahanzeb, MD, discusses therapeutic agents that may fit into the adjuvant setting treatment paradigm for HER2-positive breast cancer, the increasing importance of genomic testing, and individualized treatments as multiple agents emerge.
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PD-L1 Inhibitor Avelumab May Improve Survival in Metastatic Urothelial Carcinoma
October 7th 2015Andrea B. Apolo, MD, explains the challenges that still remain regarding toxicity and future combination therapies with avelumab, and the potential of checkpoint inhibition in urothelial carcinoma going forward.
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Jeffrey Weber Joins NYU Langone, Plans to Expand Clinical Trial and Immunotherapy Initiatives
September 25th 2015Immunotherapy expert Jeffrey Weber, MD, PhD, will join NYU Langone Medical Center's Laura and Isaac Perlmutter Cancer Center as its deputy director and co-director of its melanoma program.
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PD-1 and PD-L1 May Be Actionable Targets in Sarcomatoid Renal Cell Carcinoma
September 21st 2015Renal cell carcinoma with sarcomatoid differentiation, a histology that is often resistant to targeted therapies and interleukin-2 immunotherapy (IL-2), may respond to anti–PD-1/PD-L1 therapies.
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Slamon Explores Evolution of HER2-Positive Breast Cancer Treatment
September 21st 2015Dennis J. Slamon, MD, PhD, discusses the impact of the ADAPT and BOLERO trials and how the increased focus on neoadjuvant therapy with trastuzumab and T-DM1 could transform the treatment of HER2-positive breast cancer.
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Birinapant May Reduce Chemoresistance, Recurrence in Certain Ovarian Cancers
September 13th 2015Sanaz Memarzadeh, MD, PhD, discusses a combination regimen of birinapant and carboplatin in patients with high-grade serous ovarian cancers and high levels of cellular inhibitor of apoptosis protein (cIAP) in their CA-125–negative cells.
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