The OncLive® News page includes the latest in clinical oncology news, including breaking regulatory decisions, clinical trial findings, pivotal and practice-changing data published in academic peer-reviewed journals, and more across solid and hematologic malignancies. Regulatory news includes new drug approvals by the FDA and European Union, priority review and breakthrough therapy designations, and orphan drug and fast track statuses.
Antibodies for Common HPV Strain Found in One-Third of Patients with Oropharyngeal Cancer
July 24th 2013Approximately one-third of cases of oropharyngeal cancer carried antibodies to one of the driver proteins from HPV16, and those antibodies could be detected more than 10 years prior to the diagnosis of the cancer.
Two Studies Show Efficacy of Ibrutinib in Hematologic Malignancies
June 24th 2013Patients with chronic lymphocytic leukemia and mantle cell lymphoma showed high response rates to therapy with the novel targeted therapy ibrutinib, further solidifying the safety and efficacy of a drug that has proven very promising in early clinical trials.
Elotuzumab Combination Therapy Shows Promise in Previously Treated Multiple Myeloma
June 20th 2013Patients with previously treated multiple myeloma responded well to therapy with the monoclonal antibody elotuzumab in combination with lenalidomide and low-dose dexamethasone, with a high objective response rate and longer progression-free survival.
Supreme Court Limits Ability to Patent Genes in Landmark Decision
June 13th 2013After years of varying decisions by lower courts regarding the patents held on a test for genetic mutations associated with breast cancer, the US Supreme Court has ruled that a segment of DNA in isolation is a natural product and not eligible for patent protection.
FDA Approves Lenalidomide for the Treatment of Mantle Cell Lymphoma
June 5th 2013The immunomodulatory agent lenalidomide is now approved by the FDA to treat patients with mantle cell lymphoma who have relapsed or whose disease has progressed after two prior therapies including at least one prior treatment with bortezomib.
Dabrafenib and Trametinib Both Approved for Advanced Melanoma
May 29th 2013The FDA approved both dabrafenib and trametinib for the treatment of patients with metastatic or unresectable melanoma, as well as a companion diagnostic to properly identify the patients exhibiting the mutations that are targeted by these agents.
FDA Approves Frontline Erlotinib With Novel Companion Diagnostic for Advanced NSCLC
May 14th 2013The FDA concurrently approved erlotinib along with a companion diagnostic to be used together in the first-line treatment of patients with metastatic non-small cell lung cancer harboring a specific EGFR mutation.