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ADCs in Breast Cancer: Mechanism of Action, and Components

Medical experts discuss the distinct mechanisms and components of different antibody-drug conjugates (ADCs), including the drug, antibody, and linker, and how these components contribute to the mechanisms of ADC-related toxicities.

Video content above is prompted by the following:

  • What are the different mechanisms between these antibody-drug conjugates (ADCs), as well as the different components that make up these ADCs (ie, drug, antibody, linker)?
  • Please briefly comment on how the different ADC components relate to the mechanism of some of the ADC-related toxicities.

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3 experts are featured in this series.
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Sagar D. Sardesai, MBBS
DB-12
Albert Grinshpun, MD, MSc, head, Breast Oncology Service, Shaare Zedek Medical Center