Opinion

Video

Brief Overview of Synovial Sarcoma: What It Is, Clinical Presentation and Diagnosis

Panelists discuss how synovial sarcoma is a rare soft-tissue cancer characterized by its unique SS18::SSX fusion oncogene transcript, which distinguishes it from other sarcomas and drives its aggressive behavior through altered epigenetic regulation, despite its misleading name suggesting origin in synovial tissue.

Video content above is prompted by the following:

  • What is synovial sarcoma, and how does it differ from other types of soft-tissue sarcomas?
  • How does the SS18::SSX fusion oncogene define this rare malignancy?

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Brian A. Van Tine, MD, PhD
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