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Adverse Event Management in HR+/HER2– Advanced Breast Cancer: PI3K/AKT/PTEN Pathway

Clinical Experience with Capivasertib

Video content above is prompted by the following:

Can you share your clinical experience with capivasertib and your patient’s tolerability?

Videos

Panelists discuss how targeted therapies and effective management of adverse events, particularly in relation to the PI3K/AKT/PTEN pathway, are crucial for optimizing treatment outcomes in hormone receptor (HR)–positive, HER2-negative advanced breast cancer.

Panelists discuss how biomarker testing plays a critical role in hormone receptor–positive, HER2-negative advanced breast cancer, emphasizing the timing of testing, the relevance of specific genomic assays, and the significant impact on prognosis and treatment decisions.

Insights on Biomarker Testing in HR+/HER2- Advanced Breast Cancer

Panelists discuss how to approach selecting first-line treatment options for hormone receptor–positive, HER2-negative advanced breast cancer by providing an overview of standard-of-care options and highlighting the primary considerations that guide treatment selection.

First-Line Treatment Strategies for HR+/HER2- Advanced Breast Cancer

Panelists discuss how aberrations in the PI3K/AKT/PTEN pathway drive treatment resistance and disease progression following first-line therapy in hormone receptor–positive, HER2-negative advanced breast cancer, emphasizing the critical role of repeat biomarker testing to guide ongoing treatment strategies and enhance patient outcomes.

Role of PI3K/AKT/PTEN Pathway in HR+/HER2- Advanced Breast Cancer

Panelists discuss the findings of the CAPItello-291 trial, which investigated capivasertib combined with fulvestrant in advanced hormone receptor–positive, HER2-negative breast cancer, leading to its approval in November 2023 and highlighting its potential as a new targeted therapy option in the second-line setting due to the prevalence of PIK3CA, AKT1, and PTEN alterations.

Overview of the CAPItello-291 Trial

Panelists discuss their clinical experiences with capivasertib, focusing on patient tolerability and the management of adverse effects associated with this targeted therapy.

Panelists discuss the strategies they employ to manage adverse events in patients starting capivasertib, including minimizing the risk of diarrhea through dietary considerations and patient education, as well as approaches for monitoring and managing rash associated with the treatment and providing education about it.

Adverse Event Management: Strategies for Reducing Diarrhea Risk in Capivasertib Therapy

Panelists discuss their approach to monitoring and managing hyperglycemia in patients receiving capivasertib and providing education about it, including when to involve endocrinology and how management strategies may differ for patients with preexisting diabetes.

Managing Capivasertib Side Effects: Strategies for Educating, Monitoring, and Addressing Rash and Hyperglycemia

Panelists discuss the key advice they would offer to fellow physicians, nurse practitioners, advanced practice providers, and pharmacists involved in the care of patients on capivasertib, emphasizing best practices for patient management and communication.

Clinical Experience with Capivasertib

EP: 1.Insights on Biomarker Testing in HR+/HER2- Advanced Breast Cancer

EP: 2.First-Line Treatment Strategies for HR+/HER2- Advanced Breast Cancer

EP: 3.Role of PI3K/AKT/PTEN Pathway in HR+/HER2- Advanced Breast Cancer

EP: 4.Overview of the CAPItello-291 Trial

EP: 5.Clinical Experience with Capivasertib

EP: 6.Adverse Event Management: Strategies for Reducing Diarrhea Risk in Capivasertib Therapy

EP: 7.Managing Capivasertib Side Effects: Strategies for Educating, Monitoring, and Addressing Rash and Hyperglycemia

EP: 8.Best Practices in Managing Patients on Capivasertib

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