Clinical Scenario: A 57-Year-Old Woman With Metastatic Breast Cancer

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EP: 1.Clinical Scenario: A 57-Year-Old Woman With Metastatic Breast Cancer

EP: 2.Current First-Line Systemic Therapy Options for HER2+ Metastatic Breast Cancer

EP: 3.Key Clinical Trials in the First-Line Treatment of HER2+ Metastatic Breast Cancer

EP: 4.Standard of Care Regimens for Second-Line Treatment of HER2+ Metastatic Breast Cancer

EP: 5.Sequencing Therapies in the Third-Line and Beyond for Patients With HER2+ Metastatic Breast Cancer

EP: 6.Clinical Scenario: A 65-Year-Old Post-Menopausal Woman With Metastatic Breast Cancer

EP: 7.Approaches to Mutation Testing for Patients With HR+/HER2-low mBC and ET-Resistant Disease

EP: 8.Factors for Consideration When Choosing Among Options for Patients with ET-resistant ER+/HER2- mBC

EP: 9.Sequencing Antibody-Drug Conjugates (ADCs) in HR+/HER2-Low Metastatic Breast Cancer

EP: 10.Exciting Data in the Treatment of HER2-low from SABCS 2023

The video opens with Laura Spring, a breast medical oncologist from Mass General Cancer Center and Harvard Medical School, welcoming viewers to a program on interpreting the latest data for breast cancer treatment approaches. She introduces her colleague, Dr. Manali Bhave, a breast medical oncologist from Emory University and director of the phase one unit.

Bhave presents a hypothetical patient case of a 57-year-old healthy woman diagnosed with invasive ductal carcinoma in her left breast after a 4cm mass was found on mammogram. The tumor was estrogen, progesterone and HER2 positive with an IHC of 3+. Scans revealed metastatic disease with three 3cm liver lesions and a solitary lung lesion. A liver biopsy confirmed metastatic triple positive breast cancer.

The patient received 6 cycles of docetaxel, trastuzumab, and pertuzumab (THP) followed by maintenance HP. She had a good response with the breast mass shrinking and complete resolution of the liver lesions initially. However, after some time on maintenance HP, she progressed with recurrence of 3 new liver lesions, though her liver enzyme levels remained normal.

Bhave and Spring proceed to discuss how they would approach treating this patient's recurrent metastatic HER2+ breast cancer, incorporating the latest clinical data and pivotal trials in their decision-making process. The case illustrates their real-world application of recent research advances.

This summary was AI-generated and edited for clarity.