Dr. Hurvitz on the Findings of DESTINY-Breast01 in HER2+ Metastatic Breast Cancer

Sarah A. Hurvitz, MD, medical oncologist, medical director, Clinical Research Unit for University of California, Los Angeles Jonsson Comprehensive Cancer Center, discusses the findings in the DESTINY-Breast01 trial of patients with HER2-positive metastatic breast cancer.

This was a single-arm, phase II study in which patients with HER2-positive metastatic breast cancer received fam-trastuzumab deruxtecan-nxki (Enhertu; DS-8201). Patients enrolled on the trial received a median of 6 prior lines of therapy.

Results showed that fam-trastuzumab deruxtecan-nxki led to an overall response rate of 60.3% and the median progressive-free survival was 16.4 months.

In reflecting on the future treatment of patients with HER2-positive metastatic breast cancer, Hurvitz stressed the importance of ongoing phase III randomized trials to regularize the future treatment of fam-trastuzumab deruxtecan-nxki.