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My Treatment Approach: Chronic Lymphocytic Leukemia
Volume1
Issue 1

Dr. Lunning on Initial Treatment Considerations in CLL

Matthew A. Lunning, DO, discusses initial treatment considerations in chronic lymphocytic leukemia.

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    Matthew A. Lunning, DO, assistant professor, Internal Medicine Division of Oncology & Hematology, University of Nebraska Medical Center, discusses initial treatment considerations in chronic lymphocytic leukemia (CLL).

    Patients with CLL often present with asymptomatic disease that is identified with a routine complete blood count, Lunning explains.

    To confirm a CLL diagnosis, patients typically undergo flow cytometry on peripheral blood, says Lunning. Afterward, a lymphocyte count, hemoglobin count, and platelet count should be conducted.

    Additionally, patients should have a physical exam to identify splenomegaly, concerning adenopathy, or irregular lymph nodes, Lunning explains.

    Richter’s transformation indicates a poorer prognosis and can significantly alter a patient’s treatment in the newly diagnosed or relapsed/refractory setting, concludes Lunning.